Atropine: INDICATIONS, ACTION, SIDE EFFECTS

Atropine is a toxic substance belonging to the class of alkaloids. It is indicated in cases of cardiac disorders, hepatic colic, acute poisonings and others. Indications, action and side effects.

Definition: What is atropine?

Atropine is a toxic substance belonging to the class alkaloids; It is obtained from a molecule found in some plants The nightshade family Such as belladonna, datura, mandrake or henbane. in the form of salt (Atropine Sulfate), it is used as anticholinergic drug In certain emergency situations, before surgery before anesthesia or in the course of surgery as well as an antidote to some toxic substances (gases, pesticides, organophosphates).

How does atropine work?

Atropine is a anticholinergic substance This means that it Blocks muscarinic acetylcholine receptors In the central and peripheral nervous system. It blocks the action of this neurotransmitter in the body. The resulting effects are: Certain secretions stop (sweat, saliva, bronchial mucus, etc.), Vagus nerve inhibition (tachycardia, mydriasis, paralysis of the fitting of the lens, also called myoplasty), Smooth muscle relaxation (especially the bronchi and intestines), Agitation, delusions and depression. When used in large doses, atropine first excites the central nervous system before paralyzing it.

What are the indications for the use of atropine?

Atropine may be indicated in Emergency cases in case of cardiac disorders such as arrhythmias (atrioventricular blocks) or slow heart rate (sinus and vagal bradycardia), as well as in Hepatic colic, renal colic, intermittent pain in the gastrointestinal tract, acute poisoning by anticholinergics or parasympathomimetics (examples: nerve gas poisoning, mushrooms, etc.), in the management of squint (deterioration of eyesight), in ciliary (pharmacological paralysis of accommodation and causing dilated pupils, a technique used to perform eye examinations) or in the case of uveitis. Atropine is also used as part of a Before general anesthesia Or to avoid the harmful effects of certain medications during surgery.

What medicines contain atropine?

Atropine is present in eye drops (for example: Atropine Alcon®)Injectable solutions (eg: Atropine Sulfate (Lavoisier®) In combination with other active ingredients as in Ineurope®.

When do you take an atropine injection?

Parenteral atropine is indicated in the management of heart troubles (medical emergencies) such as atrioventricular block, sinus and vagus bradycardia, as well as in the management of Hepatic colic, renal colic, intermittent digestive pain or even acute poisoning by anticholinesterase or parasympathomimetics.

When do you take atropine drops?

In the form of eye drops, atropine is used in the management of squint (changes in vision), ciliary (a pharmacological technique for anti-adaptation and mydriasis for eye examinations), Keratitissubordinate uveitis and the ciliary body (Inflammatory reactions in the uvea and iris).

What is the dose of atropine?

atropine In eye drops at a dose of 0.3%, 0.5% or 1%. atropine The injection dose is 0.1, 0.2, 0.25, 0.5, 1 or 2 mg/mL According to work specializations.

What are the side effects of atropine?

The most common side effects are visual disturbances (dilated pupils, blurred vision, intolerance to light), a Decreased bronchial and gastric secretionssubordinate dry mouth (with difficulty swallowing or speaking and feeling thirsty), decrease in sweating subordinate digestive disorders (constipation, heartburn, nausea, vomiting, flatulence), uLoss of taste, dry skin and rashes (or hives). Other effects may also occur, especially with higher doses, such as Agitation, coordination problems, confusion, hallucinations, high body temperature, heart problems (tachycardia, arrhythmia, bradycardia), blushing and the difficulty urinating Psychotic reactions, allergic reactions, seizures, drowsiness, severe allergic reactions, ventricular fibrillation, chest pain, or rapid rise in blood pressure have been reported rarely.

What are the contraindications of atropine?

Contraindications to atropine do not apply in cases where its use is in a life-threatening situation. Atropine is contraindicated in hypersensitivity to atropine or to any of the excipients contained in the medicinal product. It is also contraindicated In the case of a history of angle-closure glaucomain case difficulty urinating (urinary retention associated with prostatic urethral disorders), Esophageal disease and intestinal obstruction (paralytic ileus), Colon distension (toxic megacolon) or during Breastfeeding. Care must be taken in case Enlarged prostate, kidney or liver failure, heart failure, arrhythmia or hyperthyroidism, chronic obstructive pulmonary disease (chronic obstructive pulmonary disease) Pyloric stenosis (stomach), Fever (or high ambient temperature). Caution is also required in echildren and the elderly, who are more susceptible to adverse effects.

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