When DNA damage to mitochondria affects cell cycle progression

© Nicholas Chevigny

In flowering plants, the mitochondrial genome is very large and dynamic and its stability affects plant health and development. In a study published in the journal PLoS Geneticsscientists showed that RADA DNA helicase fromArabidopsis Necessary for the stability of mitochondrial DNA, and its absence affects the development of Plant (Plants (Plantae Haeckel, 1866) are multicellular organisms at the base of…) Across I’Can (Activation may refer to:) of the genes that inhibit the development of cell cycle (The cell cycle is the set of stages through which a cell passes between two divisions…). These results help to understand the rapid development of Mitochondrial genome (Mitochondria are organelles found in the vast majority of cells…) In plants as well as her interaction (An interaction is the exchange of information, influences or energy between two agents within…) With expression of nuclear genes.

In plants, mitochondrial DNA rearrangements by recombination are responsible for their very rapid development, and can give rise to valuable agricultural traits, such as cytoplasmic male sterility, used by breeders to produce hybrid seeds.

Scientists have shown that RADA DNA helicase is essential for the stability of genome (The genome is all the genetic material of an individual or…) Mitochondria. RADA speeds up the solution of the recombination argument, turning it into Arabidopsis It causes major genome rearrangement by uncoordinated duplication of subgenomes resulting from recombination. unlike bacteria (Bacteria (Bacteria) are prokaryotic unicellular organisms, characterized by …) Where RADA is not essential and is partially overexpressed with RecG helicase, in plants RADA appears to be the main pathway to resolve certain mediators (‘branch migration’) during DNA recombination.

Scientists also show that an important component of mutant growth defects rad is the answer receding (An object in the solar system is said to have retrograde motion if it performs…) (affiliate Mitochondria (Mitochondria (from the Greek mitos, thread and chondros, grain) is an organelle inside…) to nucleolus) resulting from damage to the mitochondrial genome, resulting in the activation of nuclear genes that suppress cell cycle progression. These responses are likely to be mediated by increased production of reactive species ofOxygen (Oxygen is a chemical element of the family of chalcogens, from…) (“ROS”) emanating from mitochondria. Thus RADA appears to be a key factor in the maintenance machinery of mitochondrial DNA, which is capable of generating genetic diversity (Genetic diversity is a characteristic that describes the level of…) At the mitochondrial DNA level. These results highlight the importance of better understanding the mitochondrial recombination pathways in plants and their relationship to nuclear gene expression.

Diagram showing the potential retrograde regulation of factors that inhibit the cell cycle in response to mitochondrial DNA damage. The release of reactive oxygen species (ROS) from mitochondria can be Signal (General terminology A signal is a simplified message and is generally encrypted. There is…) It translocates to the nucleus, capable of direct activation of cell cycle regulators that depend on the transcription factor SOG1. Other signaling and/or pathways may be involved, including changes in the epigenome.
© Jose Gualberto

To find out more:
RADA-dependent branch migration has a predominant role in plant mitochondria and its defect leads to mtDNA instability and cell cycle arrest
Nicolas Chevigny, Frédéric Weber-Lutfi, Anis Le Plevnik, Cedric Naderas, Arnaud Fertit, Marc Bechara, Matthew Erhardt, Andre Dietrich, Cecile Raynaud, Jose M Gualberto.
Plus Genetics (Genetics (not to be confused with the Journal of Genetics) is a scientific journal…) May 12, 2022. https://doi.org/10.1371/journal.pgen.1010202

. institute molecular biology (Molecular biology (sometimes abbreviated bio mol or BM) is a specialty…) Number of Plants – IBMP (CNRS / University of Strasbourg)
12 Street (The street is a trading space in the city that serves housing and places…) General Zimmer 67084, Strasbourg, France.

Jose Gualberto – Researcher (Researcher (researcher) refers to a person whose job it is to conduct research…) CNRS (The National Center for Scientific Research, better known by the acronym CNRS, is the largest…) In theinstitute (An institute is a permanent organization established for a specific purpose. It is…) From biology (Biology, commonly known as “bio”, is the science of life….) Plant Molecules – IBMP (CNRS / University of Strasbourg) – jose.gualberto at ibmp-cnrs.unistra.fr

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