HIV-1 intracellular transport overcomes the prevention of virus entry into macrophages


© Serge Benichou

While macrophages are important targets of HIV-1 He livesInfection tests aim to rehabilitate orbital cells in the laboratory suggests that the isolated viruses are primarily T-cell tropical and rarely macrophage, and thus do not reflect the conditions of infection. He lives. A study published in the journal Pathogens PLOS demonstrates that intracellular viral transmission of infected T cells overcomes the ban on entry to isolates identified as non-administered macrophages.

Understanding how HIV-1 hijacks immune cell functions to promote viral spread remains a challenge in infection control. Macrophages are ubiquitous tissue-resident cells involved in tissue homeostasis and immunity. In HIV-1 infection, macrophages serve (The server is a contraction of the word server and the client.)with CD4 + T lymphocytes, vectors for propagation virus (A virus is a biological entity that requires a host cell to use…) and persistent tissue viral depots, which presents an obstacle to HIV-1 eradication. However, the mechanisms involved in macrophage infection are still not fully understood. a paradox (An inconsistency is a subtraction that contains or appears to contain a logical contradiction, or…) is that infected macrophages are present in a wide range of tissues while tests orbital (The term Tropism comes from the Greek meaning “to give direction”). cellular in the laboratory Indicate that only one number (The notion of number in linguistics is addressed in the article “Number …) A limited number of HIV-1 isolates can enter macrophages.

The scientists speculated that these tests, which assess infection using virus-free particles, may not fully reflect macrophage infection patterns. He lives in infected patients. They show that the transmission of the virus between cells by fusion (In physics and metallurgy, fusion is the transition of an object from a solid state to…) Intracellular interaction with infected CD4+ T cells represents a highly effective method for infecting macrophages, even with isolation of virus characterized as non-tropical to macrophages in free virus infection assays. This intracellular viral transport is facilitated by increased interactions between HIV-1 envelope glycoproteins, CD4 cellular entry receptors, and chemoreceptors CCR5 and CXCR4. These results indicate that HIV-1 possesses a much larger upregulation area for macrophages than originally suggested.

Highlight these results light (Light is the set of electromagnetic waves visible to the eye…) The role of this pathway of cell-to-cell-to-macrophage transmission in CD4+ T-cell-rich tissues is for the transmission, dissemination and formation of tissue viral reservoirs for HIV-1. The scientists suggest that infection of macrophages by intracellular viral transmission could affect various aspects of the pathophysiology of HIV-1 infection, thus renewing our understanding of the role of macrophages in pathogenesis and insistence (Insistence (statistics) persistence (computing) in drawing: …) of HIV-1.


© Serge Beniceau.

Figure: Model of intracellular transport and spread of HIV-1 to macrophages from infected CD4+ T cells. Primary virus transduction and subsequent viral spread within macrophages are mediated by the two-step cell fusion process. start time (Time is a concept developed by humans to understand…)Infected T cells establish contacts and then fuse with macrophage targets (pink in the figure). Newly infected cells gain the ability to fuse with surrounding uninfected macrophages, resulting in the formation of multinucleated giant cells capable of producing large amounts of infectious virus.

To find out more:
Cell-to-cell spread of HIV-1 overcomes the prevention of virus entry of tropical non-macrophages into macrophages.
Han M, Cantaloube-Ferrieu V, Xie M, Armani-Tourret M, Woottum M, Pagès JC et al.
Pathogens PLoS 18 (5): e1010335.https://doi.org/10.1371/journal.ppat.1010335

Lab:
Cochin Institute (CNRS / Inserm / Paris City University) – 22 Street (The street is a trading space in the city that serves housing and places…) Michen. 75014 Paris (Paris is a French city and the capital of France and the capital of the region…).

Contact:
Serge Benichou – Director Research (Scientific research identifies in the first place all actions taken with a view to …) CNRS (The National Center for Scientific Research, better known by the acronym CNRS, is the largest…) – serge.benichou at inserm.fr

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