Peanut allergy: severe allergy, increasing

Lille, France – French-speaking pediatricians have noticed an increase in cases of food allergies and anaphylaxis in children in recent years. The latter is smaller and smaller than the others to appear with multiple allergies and multiple allergies, related to allergens with high anaphylactic potential such as peanuts.



Dr. Stephanie Legon

At the annual conference of French Pediatric Societies The Dr. Stephanie LegonPediatric Pulmonologist and Allergist (CHRU of Lille) and CIIL Team Member OplnfIELD, INSERM 1019 (Pasteur Institute Lille) has returned the most recent data on peanut allergy.

The prevalence of peanut allergy in Europe is 1.6% in children (history or positive oral provocation test). “In France, the prevalence of this allergy has increased in recent years,” comments the Dr. Stephanie Legon.

In France, the prevalence of this allergy has increased in recent years.
Dr. Stephanie Legon

Estimates ranged between 0.3 and 0.75% according to a 2005 publication, 0.7% (children aged 2-5) and 0.6% (6-17 years) in a second publication in 2005.

Latest data from the neonatal cohort dwarf (Children born in 2011) An estimated 0.93 percent of children are allergic to peanuts at an average age of 5.5 years. 59% of them suffer from multiple allergies[1].

intense and unexpected

Peanut allergy is a severe allergy: it is the leading cause of anaphylaxis (the most severe form of IgE-mediated allergy) in children, in the United States as in Europe, and to a lesser extent in Asia[2].

The severity of peanut allergy was confirmed by data from the European Anaphylaxis Registry between 2007 and 2018, where 1,962 cases of food anaphylaxis occurred in children under 18 years of age, 23% of which were due to peanuts.[3].

Overall, 85% of peanut anaphylaxis cases occurred before the age of 18 years. “This allergy is also severe because the reaction dose is low: less than a teaspoon of peanut butter in 66% of cases.”[3] ‘, confirms the pulmonologist.

This allergy is also severe because the reaction dose is low: less than a teaspoon of peanut butter in 66% of cases.
Dr. Stephanie Legon

According to the French, Belgian and Luxembourg studies mirable Published 2016 in children under 16 (mean age at diagnosis 3 years)[4], 28% of children with peanut allergy have asthma, atopic dermatitis and other food allergies, and 30% have already had to deal with anaphylaxis. The risk of developing anaphylaxis was significantly associated with adolescence and a history of asthma. Again, trigger doses were low with an average of 125 milligrams of protein (peanuts equal 150-200 milligrams of protein).

Finally, a peanut allergy is severe as it continues to lead to death, according to the Allergy Watchdog Network between 2002-2018, with 7 out of 18 deaths listed in France due to peanuts.[5].

In the UK, 14% of the 152 recorded deaths (period 1992-2018) were caused by eating peanuts[6]. This extreme sensitivity is unpredictable. The European Group of Anaphylaxis confirms this, in more than one in two cases, the occurrence of anaphylaxis outside the home. This is also true for mortality. Finally, the impact on quality of life is certain; For more than half of parents, their children’s peanut allergy is a “big” and “enormous” concern.

This extreme sensitivity is unpredictable.

Hopes

Encouragingly, two advances reported at the Congress of French Pediatric Societies could limit the occurrence of severe reactions.

In terms of prevention first, the French Society of Allergology now recommends introducing peanuts between 4 and 6 months (as with all food allergens). Clinical data showed that this early introduction made it possible to reduce subsequent events.

Also, a new oral immunotherapy drug based on arachis hypogaea should soon be marketed in France to facilitate and standardize desensitization.

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