Three children with a rare genetic disease need a kidney transplant. Using a unique transplant technology, doctors were able to replace their organs without the need for immunosuppressive drugs.
Reducing the risk of rejection without resorting to immunosuppressants during kidney transplantation
In general, after receiving a file Illegal earningOrgan recipients must take immunosuppressive drugs for the rest of their lives, to prevent their immune system from rejecting them. Thus, these patients are more likely to develop infections and cancers, and even in this case, Immunosuppressants do not completely eliminate the risk that their bodies will eventually attack the organ.
To reduce or eliminate the need for these compounds, doctors have attempted transplantation Stem Cells From the donor to the recipient, at the same time with his new organ. From the bone marrow, these cells differentiate into different types of blood cells, including types of immune cells called lymphocytes that signal the presence of any foreign body in the body.
In theory, since these stem cells come from the donor, the recipient’s organism will regard the newly transplanted organ as familiar, which will have the effect of reducing the risk of rejection. Unfortunately, stem cell transplants carry significant risks: a condition called graft-versus-host disease, in which new immune cells inadvertently target the transplant recipient’s body.
Three patients with a rare autoimmune disease
In the course of the works published in New England Journal of Medicinedoctors from stanford Develop an innovative approach to Kidney and stem cell transplantation in patients. Until now, None of the three patients who underwent this procedure required immunosuppressive therapy or the development of graft disease.
At the age of 7 to 8 years, the transplant recipient suffers from a rare immune disease called Shimke immune dysplasia (SIOD). This disease is characterized by chronic kidney failure that requires a kidney transplant, and causes bone marrow failure, including stem cell transplantation.
In the case of these three patients, one parent became a stem cell and kidney donor for their child. Doctors initially performed the stem cell transplant, and then five to ten months later, once the child had recovered from the operation, the kidneys.
Today, 22 to 34 months after the second operation, The new kidneys are working perfectly The children returned to their normal lives. ” They are real walking miracles Nobody’s mother said. ” In addition to not needing immunosuppressive treatments, they no longer showed signs of SIOD. »
baptized DISOT (dual immune solid organ transplantation)The new procedure has been approved by US Food and Drug Administration (FDA) For patients with certain diseases that have an effect on the kidneys.
Hoping that this approach will soon be approved as a treatment option for many patients who need such transplants, the team plans to study the possibility of adapting it to other solid organ transplants.
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