The mysterious and surprising effects of some painkillers on the human body revealed

Without an excess, painkillers are completely harmless. But a study showed that while pain relievers are indeed effective for some health conditions, some have unexplained and potentially dangerous health effects.

What are the analgesics, analgesics and NSAIDs?

Also known as analgesics or analgesics, these are medicines that are used to treat pain. Doliprane, Efferalgan, Dafalgan, ibuprofen; There are too many brands of pain relievers available on the market. While many brands are the same, you should know that there are several types of pain relievers, and the World Health Organization (WHO) classifies them according to the severity of the pain they can treat. In general, three types of analgesics are considered, the most common of which is “Step 1”.

Class 1 pain relievers are medications for mild and common pain, and this includes paracetamol-containing drugs and non-steroidal anti-inflammatory drugs (NSAIDs). The majority of top-tier pain relievers can be purchased without a prescription, but that doesn’t mean they are safe. In fact, a new study by researchers at Yale University shows that some of these drugs can have surprising side effects on the human body.

Discovering a new mechanism of action for NSAIDs

According to the results of the study published in the journal immunitySome NSAIDs can have negative effects on serious diseases, such as cancer and heart disease, while others are associated with a lower incidence of these same diseases. To better understand this, researchers re-examined how these drugs work. So far, researchers believe that the anti-inflammatory effects of NSAIDs are caused solely by the inhibition of certain enzymes.

But this mechanism does not take into account many clinical outcomes that differ from one drug family to another. To advance their research, the scientists conducted experiments on cell cultures and mice. In particular, they discovered a distinct mechanism by which a subgroup of NSAIDs reduce inflammation. This mechanism is specifically related to a protein called NFR2. If activated, this protein protects the cells of the body from damage caused by oxidative stress and thus prevents inflammatory processes.

While this new mechanism thus explains the effectiveness of some NSAIDs against inflammation, it does not explain why others experience adverse health effects. According to the researchers, more studies need to be done on this topic, as it could fundamentally change the use and regulations of NSAIDs. ” Because people use NSAIDs frequently, it is important to know what they do in the body. “, In particular Anna Eisenstein, lead author of the study, said in a statement. Moreover, these studies are also needed to find more effective ways to use these drugs in treating diseases such as allergies and autoimmune diseases.

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