Bisphenol A, Paracetamol, Phthalates … A study confirms that chemical pollutants change the quality of sperm

A study looked at the role of pollutants found in everyday products in the deterioration of human sperm quality. If the conclusions bolster concerns, they also raise the idea that the mixture of certain molecules is particularly worrisome.

This is another clue. A new study was published Thursday in the scientific journal international environment Confirms that a cocktail of chemical pollutants alters the quality of sperm. This observation is based in particular on the evaluation Nine co-controlled chemicals in urine samples from 98 young Danish men., we read in response to the work by Andreas Kortenkamp, ​​of Brunel University in London, and Hanne Frederiksen, professor at the Rijschuspitalt, in Copenhagen. Any one? Bisphenol A (A, F, S) found in the manufacture of electronic equipment, food packaging, paint or varnish; Phthalates (DEHP, DnBP, BBzP, DiNP) specified in the packaging of household and food products (among others), butylparaben, a preservative used in some cosmetics, and paracetamol, this well-known balm.

The result: In subjects, the mixture of these chemical compounds, which are present in many everyday consumer products, was measured at alarming levels, with a mean level of exposure about twenty times higher than the risk threshold. For some highly susceptible individuals, the level appeared 100 times higher than the acceptable limit. The study also mentions polychlorinated dioxins as a significant risk vector. There are plenty of contaminants lurking in everyday products, accused of playing a central role in the decline in male fertility, a public health scourge that has been steadily worsening for fifty years.

These substances are known to be toxic to reproduction [phénomène de toxicité pouvant altérer la fertilité, ndlr] actual or potential, Robert Baruki, an environmental toxicologist and research committee member at the Medical Research Foundation, states. According to him, the true originality of this study lies above all in the “Prioritizing substances and knowing which ones have the greatest contribution to a cocktail effect.” Because not all of them are equal.

‘Significant decline in male reproductive health’

Specifically, according to scientists, bisphenol A ‘Makes a very strong contribution’ risk, without removing it from the reduction equation Joint exposure to acceptable levels.. Paracetamol is also a risk factor for confusion in people who take the drug‘, they add. “One might think that phthalates were important agents, but their influence here is weaker.”Robert Baroque confirms. Exposures that can also affect the future fertility of the fetus.

Already in 2017, a comprehensive reference curated by Shana Swan, a world-renowned expert in environmental epidemiology and professor of public health at Mount Sinai School of Medicine in New York, has testified to ‘Significant decline in male reproductive health’ in Western countries. Swan and his team analyzed semen samples from at least 42,935 men, from Australia, Europe and North America, over a period from 1973 to 2011. Published in The Specialized Journal Human Reproduction UpdateAnd the Their findings reflect a 50% decrease in sperm concentration Over the four decades, it decreased from 99 million sperm per milliliter to 47 million. Researchers have linked “reasonable way” This big downfall of “Multiple environmental influences, including endocrine-disrupting chemicals,” It is ubiquitous in industrialized countries.

“Minimum Risk Estimation”

Since then other studies indicating altered sperm have been conducted in Denmark, Spain and China. Everyone has come up with the hypothesis of an association with chemical exposures of a different nature. Among them, the study conducted in the Wuhan area in 2018. As a result of their research, Chinese scientists reported the presence of “big drop” Sperm density in 9,357 donors, between 2010 and 2015, ‘Possibly linked to continued deterioration’ for environmental quality. “As the most populous city in central China, Wuhan forms an important part of the economic zone along the Yangtze River, which suffers from severe environmental pollution, including air, water and mineral pollution. We can read in their report published in the magazine Asian Journal of Andrology. We hypothesize that pollutants may play a major role in altering human spermatogenesis.”

And in a report unveiled in February to launch the “national strategy” to fight infertility in France wanted by the government, The influence of environmental factors Qualified as “A major topic unknown to the public and health professionals.” Co-editor of the document, Professor Samir Hamama, Head of the Department of Reproductive Biology at Montpellier University Hospital, warned in Release On the need to open our eyes: “The role of products that are toxic to reproduction, such as heavy metals, pesticides, and endocrine disruptors, that are present in our everyday environment, in the air, in our workplaces, and in our food, without any classification showing that they are toxic to reproduction… All these things will change the quality and quantity man’s sperm.”

There is scientific consensus that lifestyle factors such as eating disorders, stress, and smoking are also primary factors for the decline in male reproductive health. realize that a file “The reasons for this worrying development have not been fully elucidated.”in particular because ambiguity remains regarding the exact responsibility of both societal and environmental factors, the authors of the study published Thursday remain less strict about the main impact of the pollutants analyzed. “Our assessment of the risks of chemical mixtures affecting male reproductive health reveals disturbing excesses of acceptable co-exposure, Scientists conclude in their article. Given the lack of data that we had to deal with, this assessment should be considered as a lower estimate of risk.”

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